Irf3 transcription factor

Author: xeyq

August undefined, 2024

WebIRF3 is a transcription factor which is a major regulator of the type I interferon (IFN) antiviral response after recognition of viral DNA or RNA by intracellular foreign nucleic acid sensors, such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and cyclic GMP-AMP synthase (cGAS) (reviewed in [10]). IRF3 activa-

IRF3 prevents colorectal tumorigenesis via inhibiting the …

WebThe downstream signaling pathways from PRR activation phosphorylate ubiquitously expressed IRFs (IRF1, IRF3, and IRF7) through IRF kinases, such as TANK-binding kinase 1 … WebNov 20, 2024 · Interferon Regulatory Factors (IRFs) are a family of transcription factors that signal downstream of multiple pathways, including Toll-like receptor (TLR), retinoic acid-inducible gene I (RIG-I), melanoma differentiation associated gene 5 (MDA5), and B cell receptor (BCR) signaling pathways to regulate gene expression involved in both innate … pop warrior within setup download

IRF3 and IRF7 require SIRT1 for liquid–liquid phase ... - Nature

WebOct 15, 2024 · Transcription factors for expression of IRF3 engage its gene locus located on human chromosome 19q13.3–13.4 . The structural gene is composed of eight exons, which include a 5′UTR. Several laboratories uncovered critical domains of … WebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is posttranslationally modified by protein phosphorylation at multiple serine and threonine residues, located in the carboxy-terminus of IRF-3. WebMay 27, 2024 · Thereafter, TBK1 in this signalosome phosphorylates C-terminus of interferon regulatory factors 3 (IRF3), which mobilizes IRF3 for dimerization and nuclear translocation, where it functions as transcription factor to induce the expressions of type I interferons (IFN-Is), various cytokines, and subsequently a multitude of IFN-stimulated … pop warrior within system requirements

Regulation of adipogenic differentiation and adipose tissue ... - Nature

IRF3 - an overview ScienceDirect Topics

WebJun 1, 2024 · The interferon regulatory factor (IRF) family of transcription factors play a vital role in the human innate antiviral immune responses with production of (IFNs) as a hallmark outcome of activation. In recent years, IRF3 Graphical abstract Keywords IKKε NAP1 TBKBP1 TANK Abbreviations IRF Interferon regulatory factor IFNs Interferons TI-IFNs WebThe interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the alpha beta interferon (IFN-alpha/beta) gene promoters, as well as the interferon-stimulated response element (ISRE) of some IFN-stimulated genes. IRF-3 was orig … pop warrior within torrent downloadWebApr 14, 2003 · The transcription factors interferon regulatory factor 3 (IRF3) and NF-κB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of ... pop warrior within walkthrough

"WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … " - Irf3 transcription factor

Irf3 transcription factor

Autophagic degradation of IRF3 induced by the small-molecule ... - PubMed

WebJul 25, 2024 · The discovery Interferon-regulatory factor 3 (IRF3) and IRF7 are the two pivotal transcriptional factors that directly control the production of IFN-α and IFN-β, determining the antiviral... WebDec 4, 2024 · IRF3 and IRF5 are phosphorylated by protein kinases, which are activated by signalling pathways of pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) that signal via TRIF (TLR3 and TLR4) and MyD88 (e.g. …

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WebJun 5, 2024 · Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. However, the role of IRF3 in obesity and obesity-associated disorders remains unclear. Here, we show that IRF3... WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) serves as an indispensable transcription factor for type I IFN production. After receiving upstream signals, IRF3 goes through diverse processes to activate the type I IFN signaling, including phosphorylation, dimerization, translocation to nucleus and stimulation of DNA binding and transcriptional activity ...

WebPreviously, it was shown that IRF3 is a downstream transcription factor that regulates the expression of IFNβ induced by TRIF-dependent TLRs 28, 29. ... 22, via the inhibition of NLRP1 and NLRP3 inflammasome, or via induction of IL-10 who then through activation of STAT3 transcription factor reduced the abundance of pro-IL-1a and pro-IL-1β. WebApr 11, 2024 · TLR signaling cascades typically converge on transcription factors such as NFκB, AP-1, and IRF3 that initiate the synthesis of a battery of innate immune effectors involved in antibacterial ...

WebMar 21, 2024 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and … WebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, …

WebNov 1, 2012 · IRF3 and IRF7 have multiple sites that—upon viral infection—are substrates for phosphorylation by the serine/threonine kinases TANK-binding kinase 1 (TBK1) and IκB …

WebInterferon regulatory factor 3 (IRF3) is a key transcription factor activated in response to virus infection and is largely responsible for establishing an antiviral state in the infected... pop warrior within full screenWebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of … sharon riveraWebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. Mechanistically, IRF3 binds the NF-κB–p65 subunit and prevents its … pop warrior within trainer for pcWebOct 15, 2024 · Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly … sharon rivasWebUsing cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. … pop warrior within full game download for pcWebTranscription factors IRF3 activates toll-like receptor-independent type I IFN production, which are very important in inducing IFN-γ production. 32 IFN-α/β is one of the most … sharon rivera facebookWebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses. sharon rizo fitness