Cisplatin adducts

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August undefined, 2024

WebIn nDNA, cisplatin-DNA adducts are removed and DNA is repaired by nucleotide excision repair (NER). Mitochondria do not have NER mechanisms for mtDNA. We demonstrate that cisplatin forms adducts with mtDNA in DRG neurons, and that this alters mtDNA replication and transcription. WebMay 8, 2014 · The masses of the platinum adducts following digestion and separation by HPLC were measured by mass spectrometry. Our results demonstrate that hydrated electrons induce damage to thymines as well as detachment of the cisplatin moiety from both guanines in the oligonucleotide.

Biomolecules Free Full-Text Cisplatin Resistance: Genetic and ...

WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … focal fatty change liver

cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum…

WebCisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer cells cope with the drug by removal of the damages with nucleotide excision repair. We … WebThis mixture is heated from 20^ {\circ} \mathrm {C} 20∘C to 200^ {\circ} \mathrm {C} 200∘C while flowing through a tube in which the pressure is maintained at 150 kPa. Determine the heat transfer to the mixture per unit mass of the mixture. Verified answer. physics. A 32.0-\Omega 32.0−Ω resistance coil uses 375 \mathrm {~W} 375 W of power. WebMay 8, 2014 · The masses of the platinum adducts following digestion and separation by HPLC were measured by mass spectrometry. Our results demonstrate that hydrated … greers laundry williston

Decreased cisplatin/DNA adduct formation is associated with …

Sensitive detection of DNA modifications induced by cisplatin and ...

WebCisplatin is an effective, widely used drug for many cancers, which shows a high level and broad spectrum of antitumor activities. (1−6) It has been known that the binding between this drug molecule and the DNA molecule disables the physiologic activities of DNA and eventually induces cell apoptosis. WebDetection and characterization of an individual cisplatin adduct on a single DNA molecule is a demanding task. We explore the characteristic features of cisplatin adducts in the … greers lillian alabamaWebJul 1, 2001 · Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA and forms 1,2-d(ApG), 1,2-d(GpG) and 1,3-d(GpTpG) intrastrand … focal femoral deficiency syndrome

"WebCisplatin adducts are Guanine-Guanine (GG) DNA intrastrand cross links caused by the chemical compound Cisplatin. Cisplatin is used as a chemotherapy agent that contains … " - Cisplatin adducts

Cisplatin adducts

WebMay 7, 2024 · The formation of adducts between cisplatin and nuclear DNA is not the only mechanism by which cisplatin induces cytotoxicity, and cisplatin also has significant toxicity to enucleated cells.[6 7] Some studies have shown that oxidative stress is related to cisplatin-induced cytotoxicity, and cisplatin induces intracellular reactive oxygen ... WebThe cytotoxicity of platinum compounds is thought to be determined primarily by their DNA adducts. Cisplatin and oxaliplatin are structurally distinct, but form the same types of …

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WebThe kinetics of bifunctional cisplatin adduct formation were studied with DNA in vitro and in cultured Chinese hamster ovary (CHO) cells. Prior to adduct measurements with AAS in … WebSep 5, 2011 · The recognition of inter- and intra-strand DNA adducts and the consequent generation of an apoptotic signal is often impaired in cisplatin-resistant cancer cells …

WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the … WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by …

WebMar 29, 2006 · Here we describe a new method to establish and characterize monoclonal antibodies (Mab) for structurally defined DNA adducts. The two major reaction products of cisplatin, the guanine-guanine (Pt- [GG]) and adenine-guanine (Pt- [AG]) intrastrand crosslinks are recognized by Mab R-C18 and R-B3, respectively. WebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response …

WebNov 7, 2016 · Cisplatin, one of the most widely used anticancer drugs, crosslinks DNA and ultimately induces cell death. However, the genomic pattern of cisplatin-DNA …

WebHuman colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteins These results indicate that high-level resistance of human colon cancer cells to high doses of cisplatin and oxaliplatin does not seem to be related to acquired defects in the DNA MMR proteins. focal fibroglandular tissueWebCisplatin is considered to be the most active platinum agent drug. Neoadjuvant (or induction) chemotherapy can be used for cervical cancer patients with locally advanced disease; this treatment is followed by radical surgery and/or radiation therapy. Cisplatin is considered to be the most active platinum agent drug greers mccrary rdWebThe DNA adducts of cisplatin are thought to mediate its cytotoxic effects by inhibiting DNA replication and transcription and, ultimately, by inducing programmed cell death, or … greers lillian highway pensacola flWebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel … focal fit training studioWebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, … focal firm翻译 greers lillian hwy pensacolaWebThe cytotoxicity of platinum compounds is thought to be determined primarily by their DNA adducts. Cisplatin and oxaliplatin are structurally distinct, but form the same types of adducts at the same sites on DNA. However, the DNA adducts are differentially recognized by a number of cellular proteins … greers mcintosh al address