WebOct 23, 2024 · In contrast both BLM and bacterial RecQ helicases feature a significantly shorter β-hairpin (Figure 2C) that makes polar interactions with the DNA junction, ... Despite these efforts the RecQ family like the wider helicase superfamily family remain largely undrugged. One of the challenges associated with these targets is the high proportion of ... WebMar 21, 2024 · BLM, the RecQ DNA helicase mutated in Bloom syndrome, is preferentially modified by SUMO-2/3 both in vitro and in vivo. BLM protein expression may play an …
641 - Gene ResultBLM BLM RecQ like helicase [ (human)]
WebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. WebRecQ helicases, including yeast Sgs1 and human BLM, have been implicated in both replication and recombination and protect genome integrity by preventing unscheduled mitotic recombination events. We have studied the RecQ helicase-mediated mechanisms controlling genome stability by analyzing replication forks encountering a damaged … kittens wearing cowboy hats
Bloom syndrome protein - Wikipedia
WebATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3"-5" direction. Participates in DNA replication and repair. Involved in 5"-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5"-ssDNA. Negatively regulates sister chromatid exchange (SCE). WebHelicases are a ubiquitous group of enzymes that use the energy of nucleoside triphosphate (NTP) hydrolysis to catalyze the separation of double-stranded nucleic acids (dsNA). The resulting single-stranded nucleic acids (ssNA) are substrates for numerous cellular reactions. WebNM_000057.4(BLM):c.1936A>G (p.Ser646Gly) AND Bloom syndrome. Clinical significance: Uncertain significance (Last evaluated: Sep 26, 2024) Review status: ... maggie smith movies full length